Recently, Dr. Huang Ting, Distinguished Researcher of the School of Pharmacy, and his laboratory team published a research paper titled "Co-immunization with DNA vaccines encoding yidR and IL-17 augments host immune response against Klebsiella pneumoniae infection in mouse model" in the internationally renowned academic journal Virulence (the top journal in Zone 1 of the Chinese Academy of Sciences). Distinguished researcher Huang Ting is the corresponding author of this paper, Lv Zheng, a master's degree candidate enrolled in 2021 of the School of Pharmacy, is the first author of this paper, and Zhang Xuan, an undergraduate student enrolled in 2020 of the School of Pharmacy, is the second author. Chengdu University is the only corresponding unit for this achievement.
Klebsiella pneumoniae is the main pathogenic bacteria of hospital-acquired pneumonia. With the continuous increase of drug-resistant strains and the lack of effective antibiotics, Klebsiella pneumoniae infection has become a prominent public health problem faced by hospitals around the world. This paper reports a new vaccine combination (p-YidR+p-IL17) against Klebsiella pneumoniae infection. The results show that the co-immunization group significantly improves the level of host immune response, reduces the number of bacteria loaded in the lung infection model of mice, decreases the lung tissue damage of mice, protects the host from Klebsiella pneumoniae infection and prolongs the life span of the host. This research provides a new idea for the research and development of new vaccines, as well as theoretical basis for the prevention and treatment of Klebsiella pneumoniae infection.
This research was funded by Sichuan Science and Technology Program, the project of Anti-infective Agent Creation Engineering Research Centre of Sichuan Province, Chengdu Industrial Cluster Collaborative Innovation Project and the International Science and Technology Cooperation Base Project of Sichuan Industrial Institute of Antibiotics of Chengdu University.
Original link:https://www.tandfonline.com/doi/full/10.1080/21505594.2024.2345019
