Recently, the research team on chiral drug and biomimetic synthesis at the College of Pharmacy of Chengdu University (CDU) published the latest research results entitled "Remote C(sp3)-H Acylation of Amides and Cascade Cyclization via N-Heterocyclic Carbene Organocatalysis" in Angewandte Chemie International Edition (IF：11.99), a top international journal of chemistry. CDU was the first affiliation. The research was highly recognized by international peers and was selected by reviewers as a Very Important Paper (VIP) in the top 5% of journals and as a front cover of the latest issue of Angewandte Chemie International Edition. Dr. Li Qingzhu, a Special Research Fellow at the College of Pharmacy, is the first author of the paper, and Zeng Rong, a postgraduate student of the College of Pharmacy enrolled in 2020, is the co-first author. Distinguished Research Fellow Li Junlong is the corresponding author of this paper.

The research is to realize organocatalytic remote C(sp3)−H acylation of amides and cascade cyclization through a radical-mediated 1,5-hydrogen atom transfer mechanism using N-heterocyclic carbene as the catalyst, which further enriches the activation strategy of the inert C(sp3)-H (as shown in the figure below). After the above research results were published, the research team was also invited to be featured in X-MOL, CBG, the official WeChat account of Wiley, and other domestic professional scientific research media. In addition, the research was supported by the National Natural Science Foundation of China, the Longquan Talent Program, and the CDU Research Projects, among other funds.

The Angewandte Chemie (a journal of the German Chemical Society (GDCh), Online ISSN: 1521-3773) is one of the flagship journals of Wiley-VCH, one of the top journals of Chinese Academy of Sciences SCI Q1, and one of the journals included in the Nature Index. It is one of the top world-class journals in chemistry, publishing highly innovative research articles with an impact factor of 15.336 (2022). 

Source:https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202116629

Cover Source: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202203258