Major Research Direction :
(1) Methodology research of organic synthesis and synthesis and research of bioactive molecules;
(2) Research on chiral new drugs based on major diseases;
(3) Development of key general chiral technologies and research on quality control of chiral drugs;
(4) Development of new processes for known drugs and generic drugs;
(5) Development and research of new uses of known drugs;
(6) Research on biomimetic synthesis.
Major Scientific Research Projects Undertaken:
1. National Key Research and Development Program for the 13th Five-Year Plan: Development of Reference Materials for Important Chemical Poisons and Deuterates, 2018.01-2022.12
2. General Program of National Natural Science Foundation of China: Research on Inert Bond Functionalization of Free Radical Process Catalyzed by Nitrogen Heterocyclic Carbene, 2021.01-2024.12
3. General Program of National Natural Science Foundation of China: Research on Asymmetric Cyclization of Heteroatom Substituted Aldehydes in a Novel Organic Small Molecule Catalytic Model, 2019.01-2022.12
4. General Program of National Natural Science Foundation of China: Research on Synthesis of Chiral Cyclic Phosphamide (Thiophosphamide) Compounds by Catalytic Asymmetric Series Reaction Involving Dialkoxy (Thio) Phosphine Isothiocyanate, 2019.01-2022.12
5. General Program of National Natural Science Foundation of China: Application of Asymmetric Cyclization Reaction Based on α-Halogenated Hydrazone in Construction of Chiral Compounds Containing Polynitrogen Heterocycles, 2016.01-2019.12
Core Research Achievements of the Team:
1. The Discovery, Development and Application of Active Substances in Traditional Chinese Medicine Based on Structure-activity Relationship, the first prize of Sichuan Science and Technology Progress Award.
2. Efficient Construction of Chiral Indole and Phenanthridine Compounds and Their Synthetic Application in Drug Molecules, second prize of Guizhou Natural Science Award.
3. Research on Tumor Mechanism and Anti-tumor Compounds Related to DNA Damage Repair, second prize of Guizhou Natural Science Award.
4. Radical Acylfluoroalkylation of Olefins through N-Heterocyclic Carbene Organocatalysis, Angew. Chem. Int. Ed. 2020, 59, 1863-1870 (SCI-JCR Zone 1, IF = 12.959).
5. Stereoselective Construction of Halogenated Quaternary Carbon Centers by Brønsted Base Catalyzed [4+ +2] Cycloaddition of a-Haloaldehydes, Angew. Chem. Int. Ed. 2018, 57, 1913–1917 (SCI-JCR Zone 1, IF = 12.959).
6. Carbonyl catalysis enables a biomimetic asymmetric Mannich reaction, Science 2018, 360, 1438–1442. (SCI-JCR Zone 1, IF = 33.611).
