Profile of Lecturer:
Zhao Fei is a distinguished research fellow and master supervisor at Chengdu University. He received a bachelor's degree from Southwest Jiaotong University in June 2010 and a Ph.D. degree from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences in June 2015. He works on drugs against benign prostatic hyperplasia, cardiovascular diseases and cancers, and conducts methodological research on the heterocyclic construction of transition metal catalysis. To date, he has hosted 9 funds including the National Science Fund for Young Scientists, and has been involved in 5 national projects including Key Program projects under the Major Research Plan of the National Natural Science Foundation of China (NSFC) and General Program projects of NSFC. He has published 30 SCI papers in renowned domestic and foreign academic journals, including 20 papers as the first/corresponding author. His research findings have been published in world-renowned academic journals like Journal of Medicinal Chemistry, Organic Letters and Chemical Communication.
Indole, a common dominant skeleton in medicinal chemistry, widely exists in nature and drugs. Indole compounds with complex and diverse structures have drawn wide attention for its considerable pharmacological activity, which makes creating a library of indole heterocyclic compounds a research interest and focus of chemists. In recent years, our research group has realized coupling reactions between indole substrates and alkyne/alkene through rhodium-catalyzed C-H activation, thereby producing indole compounds with diverse structures. This lecture will introduce the use of rhodium-catalyzed C-H activation in the synthesis of indole compounds.
Time: 10:00 am, March 12 (Friday)
Venue: Room C406, Integrated Building
Hosts: School of Pharmacy, Chengdu University and Sichuan Industrial Institute of Antibiotics